中藥大生命科學與技術學院導師：程曉東 正文

　　程曉東，現(xiàn)任中國藥科大學生命科學與技術學院長江學者講座教授、美國德州大學終身正教授，博士生導師。1985年畢業(yè)于北京大學生物系，1988年獲中科院上海生物化學研究所碩士學位，1994年獲美國德州大學博士學位。1995年至1999年，在美國加州大學圣地亞哥分校美國科學院院士Susan Taylor教授實驗室從事博士后研究。1999年起在美國德州大學任教，主要從事腫瘤細胞信號轉(zhuǎn)導過程和機制以及原癌基因調(diào)控等方面研究。

　　2001年后發(fā)表的論文：
　　1. Cheng, X., Phelps, C., and Taylor, S. S. Differential Binding of cAMP-dependent Protein Kinase Regulatory Subunit Isoforms I  and II  to the Catalytic Subunit. J. Biol. Chem. 276: 4102-4108, 2001.
　　2. Mei, F., Qiao, J., Tsygankova, O. M., Meikoth, J. L., Quilliam, L. A., and Cheng, X. Differential Signaling of cAMP: Opposing effect of Epac and PKA on PKB Phosphorylation and Activation. J. Biol. Chem., 277: 11497-11504, 2002.
　　3. Qiao, J., Mei, F., Popov, V. L., Vergare, L. A., and Cheng, X. Cell Cycle Dependent Subcellular Localization of Exchange Factor Directly Activated by cAMP. J. Biol. Chem., 277: 26581-26586, 2002.
　　4. Jabbur, J. R., Tabor, A. D., Cheng, X., Wang, H., Uesugi, M., Lozano, G., and Zhang, W. Phosphorylation at Threonine 18 of p53 Alters Hydrogen Bonding Attenuating mdm2 Binding and TAFII31 Recruitment. Oncogene, 21:7100-7113, 2002.
　　5. Li, J., Cheng, X., and Lee, J. C. Structural and dynamics of the modular halves of Escherichia coli cyclic AMP receptor protein. Biochemistry, 41:14771-14778, 2002.
　　6. Yu, S., Mei, F., Lee, J. C., and Cheng, X. Probing cAMP-dependent protein kinase holoenzyme complexes by TF-IR and chemical protein footprinting. Biochemistry, 43:1908-1920, 2004.
　　7. Young, T. W., Mei, F., Yang, G., Thomspon-Lanza, J. A., Liu, J., and Cheng, X. Activation of anti-oxidant pathways in Ras-mediated transformation of human ovarian epithelia cell revealed by functional proteomics and mass spectrometry. Cancer Research, 64:4577-4584, 2004.
　　8. Dipilato, L., Cheng, X., and Zhang, J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc. Acad. Natl. Sci. USA., 101:16513-16518, 2004.
　　9. Zhang, L., Cui, R., Cheng, X., and Du, J. Anti-apoptotic effect of serum and glucocorticoid-induced protein kinase is mediated by a novel mechanism activating I B Kinase. Cancer Research, 65:457-464, 2005.
　　10. Cheng, X. Understand signal transduction through functional proteomics. Expert Review in Proteomics, 2:103-116, 2005.
　　11. Young, T. W., Mei, F., Liu, J., Bast, R. C., Jr., Kurosky, A., and Cheng, X. Proteomic Analysis of H-Ras-mediated oncogenic transformation in a genetically defined human ovarian cancer model. Oncogene, 24:6174-6184, 2005.
　　12. Mei, F. and Cheng, X. Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton. Molecular BioSystems, 1:325-331, 2005.
　　13. Mei, F. Young, T. W., and Cheng, X. RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells. FASEB J., 20:497-499, 2006.
　　14. Brobey, R. K. Mei, F. C., Cheng, X., and Soong L. Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major. Braz. J. Infect. Dis., 10:1-6, 2006.
　　15. Yu, S., Fan, F., Mei, F., and Cheng, X. Investigating the mechanism of exchange protein directly activated by cAMP activation by FT-IR and structural modeling. Biochemistry. 45:15318-15326, 2006.
　　16. Li, J., O’Conner, K. L., Cheng, X., Mei, F. C., Uchida, T., Townsend, C. M., and Evers, B. M. Cyclic AMP-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and PKA signaling pathways. Molecular Endocrinology. 21:159-171, 2007.  
　　17. Young, T. W., Mei, F. C., Rosen, D. G., Yang, G., Li, N., Liu, J., and Cheng, X. Up-regulation of Tumor Susceptibility Gene 101 Protein in Human Epithelial Ovarian Cancer Revealed by functional proteomics. Molecular and Cellular Proteomics. 6:294-304, 2007.  
　　18. Ji, Z., Mei, F. C., Xie. J. and Cheng, X. Oncogenic KRAS suppresses GLI1 degradation and activates hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem. 282:14048-14055, 2007.
　　19. Young, T. W., Rosen, D. G., Mei, F., Li, N., Liu, J., and Cheng, X. Up-regulation of Tumor Susceptibility Gene 101 Conveys poor Prognosis through Suppression of p21 Expression in Ovarian Cancer. Clinical Cancer Research. 13:3848-3854, 2007.
　　20. Wayne, C. W., Fan, H. Y., Cheng, X., and Richards, J. S. FSH induces multiple signaling cascades: evidence that activation RAS, SRC and the EGF receptor are critical for granulosa cell differentiation. Molecular Endocrinology. 21:1940-1957, 2007.
　　21. Cheng, X., Young, T. W., and Mei, F. C. Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models. Frontiers in Bioscience. 12:5166-5176, 2007.
　　22. Brock, M., Fan, F., Mei, F., Li, S., Gessner, C., Woods Jr., V. L., and Cheng, X. Conformational analysis of Epac activation revealed using amide hydrogen/deuterium exchange mass spectrometry (DXMS). J. Biol. Chem. 282:32256-32263, 2007.
　　23. Ji, Z., Mei, F. C., Johnson, B. H., Thompson, E. B., and Cheng, X. PKA, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells. J. Biol. Chem.282:37370-37377, 2007.
　　24. Cheng, X. Silent assassin: Oncogenic Ras directs epigenetic inactivation of target genes. Science Signaling. 1:pe14, 2008.
　　25. Ji, Z., Mei, F. C., Miller, A. L., Thompson, E. B., and Cheng, X. Protein kinase A (PKA) isoform RIIβ mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. J. Biol. Chem. 283:21920-21925, 2008.
　　26. Cheng, X., Ji, Z., Tsalkova, T., and Mei, F. C. Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochimica et Biophysica Sinica. 40:651-662, 2008.
　　27. Ji, Z., Mei, F. C., Lory, P. L., Gilbertson, S. R., Chen, Y., and Cheng, X. Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer. Frontiers in Bioscience. 14:2904-2910, 2009.
　　28. Tsalkova, T., Blumenthal D. R., Mei, F. C., and Cheng, X. Mechanism of Epac activation: Structural and functional analyses of Epac2 hinge mutants with Constitutive and reduced activities.  J. Biol. Chem. 284:23644-23651, 2009.
　　29. Ji, Z., Mei, F. C., and Cheng, X. Epac, not PKA catalytic subunit, is required for 3T3-L1 preadipocyte differentiation. Frontiers in Bioscience (Elite Ed). 2:392-398, 2010.
　　
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