南京醫(yī)科大學藥學院導師:周學敏

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南京醫(yī)科大學藥學院導師:周學敏

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南京醫(yī)科大學藥學院導師:周學敏 正文


周學敏 ,教授,博導,南京醫(yī)科大學藥學院藥學系副主任,江蘇省藥學綜合實驗教學示范中心主任,江蘇省新藥評審委員會委員,江蘇省科學研究系列高級職稱評審委員,江蘇省藥物分析學會委員,全國醫(yī)藥院校藥學/中藥學實驗教學中心聯(lián)席委員會理事等。
作為課題負責人研究的各類新藥獲得國家新藥證書和生產(chǎn)批件20余項。其中“國家二類胃動力新藥鹽酸依托必利的研究與推廣” 獲得年江蘇省科技進步三等獎,第一獲獎人;“國家級新藥雙氯酚酸鉀凝膠劑研究” 獲得南京市第二屆城鎮(zhèn)婦女科技創(chuàng)造發(fā)明成果二等獎, 第一獲獎人;“鹽酸伊托必利及制劑的研究和推廣”獲得南京市科技進步三等獎,第一獲獎人。2011南京醫(yī)科大學“三育人”先進個人獎。

研究方向:
1.復雜體系微痕量物質(zhì)靶向捕獲新技術(shù)與新納米元件研究及應(yīng)用
2.多基元納米材料可控自組裝電化學傳感體系構(gòu)建及臨床應(yīng)用
3.藥物質(zhì)量控制及藥代動力學研究

近年在研與完成課題情況:
[1] 國家自然科學基金項目“基于還原氧化石墨烯和金屬納米粒層層自組裝的分子印記電化學傳感體系及臨床應(yīng)用”, (81273480,2013.1-2016.12,65萬);課題負責人
[2] 國家自然科學基金項目“功能納米硅膠表面高效率分子印記可控自組裝體系構(gòu)建及應(yīng)用研究”, (21175070,2012.1-2015.12,60萬);課題負責人
[3] 國家自然科學基金項目“基于納米硅膠表面分子印跡的固相微萃取技術(shù)用于雌激素殘留分析的研究”(20875048,2009.1-2011.12,33萬);課題負責人
[4] 江蘇省自然科學基金項目“分子印跡納米硅膠吸附劑用于農(nóng)產(chǎn)品殘留物的分析研究”,(BK2008439,2008.10-2010.12,10萬);“優(yōu)秀結(jié)題”課題負責人

已授權(quán)和申請的發(fā)明專利:
[1] 周學敏,馬靜等. “一種雌激素特異性納米硅膠表面分子印跡材料的制備方法”(NO:200910184042.4已授權(quán))
[2] 周學敏,丁美娟等. “用于檢測PDE-5抑制劑的磁性分子印記聚合物的制備方法”(NO:201010601460.1已授權(quán))
[3] 周學敏,吳曉麗等. “一種雌激素替代模板分子印跡固相微萃取萃取頭的制備方法”(NO:201110041332.0已授權(quán))
[4] 周學敏,姜慧君,李蕓等. “一種17β-雌二醇分子印記膜電化學傳感器的制備方法”(NO:201110194327.3)
[5] 周學敏,汪洋等.“啞鈴狀分子印跡攪拌棒的制備方法”(NO:201210444491.X)
[6]周學敏,姜慧君,韓青等.“一種西地那非分子印記膜電化學傳感器的制備方法”(NO:201210225721.3)
[7] 周學敏, 姜慧君,文婷婷等. “還原態(tài)石墨烯與鉑納米粒子復合材料修飾雌二醇分子印記膜電化學傳感器的制備方法”( NO: 201110446939.7 )
[8] 周學敏,王舒等.“一種雌激素納米硅膠表面樹枝狀分子印記聚合物磁珠的制備方法” (NO: 201110446939.7)
[9] 周學敏,王若禹等.“格列本脲磁性納米硅膠表面聚酰胺-胺樹枝狀分子印記聚合物的制備方法”(NO: 201110426440.X)
[10]周學敏,姜慧君,薛誠等.“一種用于檢測多巴胺的金納米粒摻雜的MES的制備方法” (NO:201310023869.3)

發(fā)表的主要SCI研究論文:
[1] Yun Li, Tingting Wen, Cheng Xue, Qing Han, Yang Wang, Junli Hong, Xuemin Zhou(通訊作者), Huijun Jiang.RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual health products. Biosensors and Bioelectronics. 2013,42:287-292
[2] Cheng Xue, Qing Han, Yang Wang, Jinhua Wu, Tingting Wen, Ruoyu Wang, Junli Hong, Xuemin Zhou(通訊作者), Huijun Jiang*. Amperometric detection of dopamine in human serum by electrochemical sensor based on gold nanoparticles doped molecularly imprinted polymers.Biosensors and Bioelectronics. 2013.49:199-203
[3] Jing Ma, Lihua Yuan, Meijuan Ding, Shu Wang, Feng Ren, Jun Zhang, Shuhu Du, Fei Li, Xuemin Zhou(通訊作者). The study of core-shell molecularly imprinted polymers of 17β-estradiol on the surface of silica nanoparticles.Biosensors and Bioelectronics,2011,26:2791-2795
[4] Lihua Yuan, Jun Zhang, Ping Zhou, Jiaxing Chen, Ruoyu Wang, Tingting Wen, Yun Li, Xuemin Zhou(通訊作者), Huijun Jiang.Electrochemical sensor based on molecularly imprinted membranes at platinum nanoparticles-modified electrode for determination of 17β-estradiol. Biosensors and Bioelectronics.2011,29:29-33
[5] Yun Li,Mei-juan Ding,Shu Wang, Ruo-yu Wang, Xiao-li Wu, Ting-ting Wen, Li-hua Yuan, Peng Dai, Yu-hui Lin, and Xue-min Zhou(通訊作者).Preparation of Imprinted Polymers at Surface of Magnetic Nanoparticles for the Selective Extraction of Tadalafil from Medicines.ACS Appl. Mater. Interfaces. 2011,3(9):3308-3315
[6] Jing Ma, LiHua Yuan, MeiJuan Ding, Jun Zhang, Qing Zhang, QunWei Xu, XueMin Zhou(通訊作者). Determination of itopride hydrochloride in human plasma by RP-HPLC with ?uorescence detection and its use in bioequivalence study.Pharmacological Research, 2009,59(3):189-193
[7] Shu Wang, Yun Li, Xiaoli Wu, Meijuan Ding, Lihua Yuan, Ruoyu Wang, Tingting Wen,Jun Zhang, Lina Chen, Xuemin Zhou(通訊作者), Fei Li. Construction of uniformly sized pseudo template imprinted polymers coupled with HPLC-UV for the selective extraction and determination of trace estrogens in chicken tissue.Journal of Hazardous Materials,2011,186(2-3):1513-1519
[8]Meijuan Ding, Xiaoli Wu, Lihua Yuan, Shu Wang, Yun Li, Ruoyu Wang, Tingting Wen, Shuhu Du, XueminZhou(通訊作者).Syntheses of Core-shell Magnetic Molecularly Imprinted Polymers and Detection of Sildena?l and Vardena?l in Herbal Dietary Supplements. Journal of Hazardous Materials. 2011,191(1-3):177-183
[9] Lihua Yuan, Jing Ma, Meijuan Ding, Shu Wang, Xiaoli Wu, Yun Li, Kunfang Ma, Xuemin Zhou(通訊作者), Fei Li.Preparation of estriol-molecularly imprinted silica nanoparticles for determining estrogens in milk tablets.Food Chemistry. 2012,131(3):1063-1068
[10]Shu Wang, Yun Li, Xiaoli Wu, Meijuan Ding, Jinhui Xu, Ruoyu Wang, Wenyu Huang, Ping Zhou, Kunfang Ma,Xuemin Zhou(通訊作者), Shuhu Du. Self-assembly molecularly imprinted polymers of E2 on the surface of magnetic nanoparticles for selective separation and detectionof estrogenic hormones in feeds.Journal of Chromatography B.2011, 879(25):2595-2600
[11] Shu Wang, Ruoyu Wang, Xiaoli Wu, Yang Wang, Cheng Xue, Jinhua Wu, Junli Hong, Jie Liu, Xuemin Zhou(通訊作者).Magnetic molecularly imprinted nanoparticles based on dendronized modification for determination of estrogens in plasma samples.Journal of Chromatography B.2012,905(15): 105-11
[12] Ruoyu Wang, Yang Wang, Cheng Xue, Tingting Wen, Jinhua Wu, Junli Hong, Xuemin Zhou(通訊作者). Selective HPLC separation and enrichment of glibenclamide in health foods using surface molecularly imprinted polymers prepared via dendritic-grafting of magnetic nanoparticles. J. Sep. Sci. 2013, 36:1015–1021
[13] Lihua Yuan,Meijuan Ding, Jing Ma,Jinhui Xu,Xiaoli Wu, Jing Feng,Fei Shen,Xuemin Zhou(通訊作者). Determination of finasteride in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry with flow rate gradient.Eur J Drug Metab Pharmacokinet,2011, 35(3-4):137-146
[14]Yun Li,MeiJuan Ding,Jing Ma,Shu Wang,XiaoLi Wu,Hui-Juan Xu,ZhengYu Lu,JianJun Zou,HongWei Fan,XueMin Zhou(通訊作者).Quantification of pantoprazole in human plasma using LC-MS/MS for pharmacokinetics and bioequivalence study.Eur J Drug Metab Pharmacokinet . 2011,35(3):147-155
[15] Jing Ma, Jing Cao, Meijuan Ding, Lihua Yuan, Meijuan Zhai, Jun Zhang, Qing Zhang,Fei Li, Xuemin Zhou(通訊作者).Separation of Fudosteine on an Achiral C18 Column by HPLC with Chiral Ligand-Exchange Selectors as Mobile Phase Additives.Acta Chromatographica, 2008,20(4):585-594
[16]Zhou Xue-Min, Liu Jie, Gao Juan, Yao Quan-Sheng, Wang Wen-Yan. Determinnation of azithromycin in human plasma by LC-MS-MS and its pharmacokinetics. Pharmazie, 2007,62(4):255-257
[17] Tingting Wen, Cheng Xue, Yun Li, Yang Wang, Ruoyu Wang, Junli Hong, Xuemin Zhou(通訊作者)and Huijun Jiang.Reduced graphene oxide-platinum nanoparticles composites based imprinting sensor for sensitively electrochemical analysis of 17β-estradiol.Journal of Electroanalytical Chemistry. 2012,682:121-127
[18] Xiaoli Wu, Jie Liu, Jinhua Wu, Yang Wang, Cheng Xue, Ruoyu Wang, Junli Hong, Xuemin Zhou(通訊作者). Molecular imprinting-based micro-stir bar sorptive extraction for specific analysis of Glibenclamide in herbal dietary supplements. J. Sep. Sci. 2012,35(24):3593-3599
[19] Xiaoli Wu, Jinhua Wu, Shu Wang, Ruoyu Wang, Yun Li, Tingting Wen, Dandan Zhong, Junli Hong, Qin Hu, Xuemin Zhoua(通訊作者). An analytical method for estrogens in milk powder by pseudo template imprinted polymers coated fiber coupled with HPLC.Analytical Method. 2012,4 (10): 3300-3306
[20] Shi Liu, Jun Yan, Guangwu He, Dandan Zhong, Jiaxing Chen, Liying Shi, Xuemin Zhou, Huijun Jiang. Layer-by-layer assembled multilayer films of reduced graphene oxide/gold nanoparticles for the electrochemical detection of dopamine. Journal of Electroanalytical Chemistry. 2012,672:40-44
[21] Na Sheng,Fangdi Wei,Wen Zhan,Zheng Cai,Shuhu Du,Xuemin Zhou,Fei Li,Qin Hu. Dummy molecularly imprinted polymers as the coating of stir bar for sorptive extraction of bisphenol A in tap water. J. Sep. Sci. 2012,35:707-712
[22] Wen Zhan,Fangdi Wei,Guanhong Xu,Zheng Cai,Shuhu Du,Xuemin Zhou,Fei Li,Qin Hu. Highly selective stir bar coated with dummy molecularly imprinted polymers for trace analysis of bisphenol A in milk.J. Sep. Sci. 2012,35:1036-1043

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