重慶理工大學(xué)藥學(xué)與生物工程學(xué)院導(dǎo)師:舒茂
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重慶理工大學(xué)藥學(xué)與生物工程學(xué)院導(dǎo)師:舒茂 正文
[導(dǎo)師姓名]舒茂
[所屬院校]
重慶理工大學(xué)
[基本信息]
導(dǎo)師姓名:舒茂
性別:
人氣指數(shù):1176
所屬院校:重慶理工大學(xué)
所屬院系:藥學(xué)與生物工程學(xué)院
職稱:副教授
導(dǎo)師類型:碩導(dǎo)
招生專業(yè):
研究領(lǐng)域:多肽藥物;藥物設(shè)計(jì)與活性評(píng)價(jià)
[通訊方式]
辦公電話:023-62563181
電子郵件:shumao@cqut.edu.cn
[個(gè)人簡(jiǎn)述]
舒茂,副教授,碩士生導(dǎo)師。2004.09-2006.06,獲重慶大學(xué)藥物化學(xué)專業(yè)碩士學(xué)位;2006.09-2009.06,獲得重慶大學(xué)生物醫(yī)學(xué)工程專業(yè)博士學(xué)位。2009.07-,重慶理工大學(xué)藥學(xué)與生物工程學(xué)院教師,2013。12-2014.12,美國(guó)國(guó)家毒理中心(NCTR/FDA)訪問(wèn)學(xué)者。在國(guó)內(nèi)外重要刊物如AminoAcids等發(fā)表論文30篇,發(fā)表論文共被他人引用200余次;授權(quán)專利1件;編寫(xiě)著作1部。獲得2010年重慶市優(yōu)秀博士論文獎(jiǎng)獎(jiǎng)1項(xiàng)。
[科研工作]
承擔(dān)的主要項(xiàng)目
[1]基于非蛋白氨基酸的小分子抗菌肽設(shè)計(jì)合成及生物效應(yīng)研究,國(guó)家自然科學(xué)基金面上項(xiàng)目,2012.1-2015.12,60萬(wàn),主持。
[2]HPV16型E7抗原CTL表位模擬肽抗HPV感染的實(shí)驗(yàn)研究,國(guó)家自然科學(xué)基金面上項(xiàng)目,2012.1-2015.12,58萬(wàn),參與。
代表性成果
[1]WangJ,ShuM,WenXR,WangYL,WangYQ,HuY,LinZH:Discoveryofvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsbyquantitativestructure-activityrelationships,moleculardynamicssimulationandfreeenergycalculation.RscAdvances2016,6(42):35402-35415.
[2]ShuM,ZaiXL,ZhangBN,WangR,LinZH:HypothyroidismSideEffectinPatientsTreatedwithSunitiniborSorafenib:ClinicalandStructuralAnalyses.PlosOne2016,11(1).
[3]ZhangWQ,NgHW,ShuM,LuoH,SuZQ,GeWG,PerkinsR,TongWD,HongHX:Comparinggeneticvariantsdetectedinthe1000genomesprojectwithSNPsdeterminedbytheInternationalHapMapConsortium.JournalofGenetics2015,94(4):731-740.
[4]YuR,WangJ,WangR,LinY,HuY,WangYQ,ShuM,LinZH:CombinedPharmacophoreModeling,3D-QSAR,HomologyModelingandDockingStudiesonCYP11B1Inhibitors.Molecules2015,20(1):1014-1030.
[5]WangYQ,ZhouPP,LinY,ShuM,HuY,XiaQY,LinZH:QuantitativePredictionofClassIMHC/EpitopeBindingAffinityUsingQSARModelingDerivedfromAminoAcidStructuralInformation.CombinatorialChemistryHighThroughputScreening2015,18(1):75-82.
[6]WangJ,ShuM,LinY,HuY,HanYZ,LinZH:HPV16E7CTLEpitopeAntigenPeptideDesignandActivityEvaluation.ProgressinBiochemistryandBiophysics2015,42(12):1119-1127.
[7]NgHW,ShuM,LuoH,YeH,GeWG,PerkinsR,TongWD,HongHX:EstrogenicActivityDataExtractionandinSilicoPredictionShowtheEndocrineDisruptionPotentialofBisphenolAReplacementCompounds.ChemicalResearchinToxicology2015,28(9):1784-1795.
[8]LuoH,DuTT,ZhouP,YangL,MeiH,NgHW,ZhangWQ,ShuM,TongWD,ShiLMetal:MolecularDockingtoIdentifyAssociationsBetweenDrugsandClassIHumanLeukocyteAntigensforPredictingIdiosyncraticDrugReactions.CombinatorialChemistryHighThroughputScreening2015,18(3):296-304.
[9]ZhangWQ,MeehanJ,SuZQ,NgHW,ShuM,LuoH,GeWG,PerkinsR,TongWD,HongHX:Wholegenomesequencingof35individualsprovidesinsightsintothegeneticarchitectureofKoreanpopulation.BmcBioinformatics2014,15.
[10]NgHW,ZhangWQ,ShuM,LuoH,GeWG,PerkinsR,TongWD,HongHX:Competitivemoleculardockingapproachforpredictingestrogenreceptorsubtypealphaagonistsandantagonists.BmcBioinformatics2014,15.
[11]LiXR,ShuM,WangYQ,YuR,YaoS,LinZH:3D-QSARAnalysisonATRProteinKinaseInhibitorsUsingCoMFAandCoMSIA.CurrentComputer-AidedDrugDesign2014,10(4):327-334.
[12]YangWJ,ShuM,WangYQ,WangR,HuY,MengLX,LinZH:3D-QSARanddockingstudiesof3-PyridineheterocyclicderivativesaspotentPI3K/mTORinhibitors.JournalofMolecularStructure2013,1054:107-116.
[13]WangYQ,LinY,ShuM,WangR,HuY,LinZH:ProteasomalcleavagesitepredictionofproteinantigenusingBPneuralnetworkbasedonanewsetofaminoaciddescriptor.JournalofMolecularModeling2013,19(8):3045-3052.
[14]TanW,MeiH,ChaoL,LiuTF,PanXC,ShuM,YangL:CombinedQSARandmoleculedockingstudiesonpredictingP-glycoproteininhibitors.JournalofComputer-AidedMolecularDesign2013,27(12):1067-1073.
[15]ShuM,YuR,ZhangYR,WangJ,YangL,WangL,LinZH:PredictingtheActivityofAntimicrobialPeptideswithAminoAcidTopologicalInformation.MedicinalChemistry2013,9(1):32-44.
[16]JiYJ,ShuM,LinY,WangYQ,WangR,HuY,LinZH:Combined3D-QSARmodelingandmoleculardockingstudyonazacyclesCCR5antagonists.JournalofMolecularStructure2013,1045:35-41.
[17]ShuM,ZhangYR,TianFF,YangL,LinZH:MolecularDockingand3D-QSARResearchofBiphenylCarboxylicAcidMMP-3Inhibitors.ChineseJournalofStructuralChemistry2012,31(3):443-451.
[18]LuoXY,ShuM,WangYQ,LiuJ,YangWJ,LinZH:3D-QSARStudiesofDihydropyrazoleandDihydropyrroleDerivativesasInhibitorsofHumanMitoticKinesinEg5BasedonMolecularDocking.Molecules2012,17(2):2015-2029.
[19]WangXY,WangJ,HuY,LinY,ShuM,WangL,ChengXM,LinZH:PredictingtheActivityofPeptidesBasedonAminoAcidInformation.JournaloftheChineseChemicalSociety2011,58(7):877-883.
[20]WangJ,WangXY,ShuM,WangYQ,LinY,WangL,ChengXM,LinZH:QSARStudyonMHCClassIAAllelesBasedontheNovelParametersofAminoAcids.ProteinandPeptideLetters2011,18(9):956-963.
[21]ShuM,LinZH,ZhangYR,WuYQ,MeiH,JiangYJ:MoleculardynamicssimulationofoseltamivirresistanceinneuraminidaseofavianinfluenzaH5N1virus.JournalofMolecularModeling2011,17(3):587-592.
[22]ShuM,ChengXM,ZhangYR,WangYQ,LinY,WangL,LinZH:PredictingtheActivityofACEInhibitoryPeptideswithaNovelModeofPseudoAminoAcidComposition.ProteinandPeptideLetters2011,18(12):1233-1243.
[23]LinY,LongHX,WangJ,ShuM,WangYQ,WangL,LinZH:QSARStudyonInsectNeuropeptidePotenciesBasedonaNovelSetofParametersofAminoAcidsbyUsingOSC-PLSMethod.InternationalJournalofPeptideResearchandTherapeutics2011,17(3):201-208.
[24]DingYA,LinY,ShuM,WangYQ,WangL,ChengXM,LinZH:QuantitativeStructure-ActivityRelationshipModelforPredictionofProtein-PeptideInteractionBindingAffinitiesbetweenHumanAmphiphysin-1SH3DomainsandTheirPeptideLigands.InternationalJournalofPeptideResearchandTherapeutics2011,17(1):75-79.
[25]YangL,ShuM,MaKW,MeiH,JiangYJ,LiZL:ST-scaleasanovelaminoaciddescriptoranditsapplicationinQSAMofpeptidesandanalogues.AminoAcids2010,38(3):805-816.
[26]CaiJF,OuRY,XuYS,YangL,LinZH,ShuM:ModelingandpredictinginteractionsbetweenthehumanamphiphysinSH3domainsandtheirpeptideligandsbasedonaminoacidinformation.JournalofPeptideScience2010,16(11):627-632.
[27]ZhuWP,YangSB,LiaoLM,TanC,ShuM:StructuralCharacterizationofVolatileComponentsofRosaBanksiaeAitforEstimationandPredictionofTheirLinearRetentionIndicesandRetentionTimes.ChineseJournalofStructuralChemistry2009,28(4):391-396.
[28]ShuM,MeiH,YangSB,LiaoLM,LiZL:StructuralParameterCharacterizationandBioactivitySimulationBasedonPeptideSequence.QsarCombinatorialScience2009,28(1):27-35.
[29]ShuM,JiangYJ,YangL,WuYQ,MeiH,LiZL:Applicationof'HESH'DescriptorsfortheStructure-ActivityRelationshipsofAntimicrobialPeptides.ProteinandPeptideLetters2009,16(2):143-149.
[30]舒茂,林治華,楊力。蛋白質(zhì)多肽序列表征方法及其應(yīng)用。西南交通大學(xué)出版社,2010年。
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